“海外名师大讲堂”系列讲座开讲通知

报告题目：新药筛选及开发研究的思路与方法

主讲人：方国伟博士

时间：2012年11月19日（周一）下午2:00--4:00

地点：西校区 逸夫馆一层 报告厅

参加人员：教师及研究生

方国伟博士简介：

方国伟博士，1987年本科毕业于南京大学生物化学专业，同年通过中美生物学交流计划项目（CUSBEA）考试赴美国科罗拉多大学博尔德分校攻读博士学位，师从诺贝尔奖得主Tom Cech教授（美国科学院院士，1989年诺贝尔化学奖），在端粒酶RNA及端粒DNA功能研究方面做出了突出成绩，其创新成果发表在《Cell》等顶级细胞生物学期刊。1994年前往哈佛大学医学院博士后师从细胞生物学系主任Marc Kirschner教授（美国科学院院士），在细胞有丝分裂检验点信号转导分子机制方面做出突破性进展，其创新成果发表在《Mol Cell》、《Nature Structure》等顶级细胞生物学期刊。1999年受聘于美国斯坦福大学任助理教授，2007年被评为副教授，他领导的科研团队揭示了Aurora A激酶调控PLK1信号转导的分子机制，相关成果发表在《Science》上。2009年起在美国基因公司任研发部负责人从事新药的研发及药物机制研究。方国伟博士获得了众多科研奖项，其中包括著名的Searle Scholar、Beckman青年科学家奖等。

欢迎广大师生前来聆听报告！

研究生院

2012/11/15

附：方国伟博士发表的部分文献

1. Maurer, T., Garrenton, L., Oh, A., Pitts, K., Anderson, D.J., Skelton, N., Fauber, B., Pan, B., Malek, S., Stokoe, D., Ludlam, M., Bowman, K., Wu, J., Giannetti, T., Starovasnik, M.A., Mellman, I., Jackson, P.K., Rudolph, J., Wang, W., and G. Fang. 2012. Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity. Proc. Natl. Acad. Sci. USA. 109: 5299-5304.

2. Wang, W., Fang, G. and J. Rudolph. 2012. Ras inhibition via direct Ras binding – is there a path forward? Bioorganic & Medicinal Chemistry Letters 22, 5766-5776.

2. Huang, X.D., Summers, M.K., Pham, V., Lill, J.R., Liu, J.F., Kirkpatrick, D.S., Jackson, P.K., Fang, G., and V.M. Dixit. 2011. Antagonism of APCCDH1 by USP37 is required for timely S-phase entry. Mol. Cell 42: 511-523.

3. Jang, C., Coppinger, J.A., Seki, A., Yates, J.R. III and G. Fang. 2009. Plk1 and Aurora A regulate the depolymerase activity and the cellular localization of Kif2a. J Cell Sci. 122: 1334-1341.

4. Seki, A., Coppinger, J.A., Jang, C., Yates, J.R. III and G. Fang. 2008. Bora and Aurora A cooperatively activate Plk1 and control the entry into mitosis. Science 320: 1655-1658.

5. Zhu, H., Coppinger, J.A., Jang, C., Yates, J.R. III and G. Fang. 2008. FAM29A promotes microtubule amplification via recruitment of the NEDD1-γ-tubulin complex to the mitotic spindle. J Cell Biol. 183: 835-848.

6. Zhao, W., Coppinger, J.A., Seki, A., Cheng, L., Yates, J.R. III and G. Fang. 2008. RCS1, a substrate of APC/C, controls the metaphase to anaphase transition. Proc. Natl. Acad. Sci. USA. 105: 13415-13420.

7. Seki, A., Coppinger, J.A., Du, H., Jang, C., Yates, J.R. III and G. Fang. 2008. Plk1- and β-TrCP dependent degradation of Bora controls mitotic progression. J. Cell Biol. 181: 65-78.

8. Jang, C., Wong, J., Coppinger, J.A., Seki, A., Yates, J.R. III and G. Fang. 2008. DDA3 recruits microtubule depolymerase Kif2a to spindle poles and controls spindle dynamics and mitotic chromosome movement. J. Cell Biol. 181: 255-267.

9. Wong, O. and G. Fang. 2007. Cdk1 phosphorylation of BubR1 controls spindle checkpoint arrest and Plk1-mediated formation of the 3F3/2 epitope. J. Cell Biol. 179: 611-617.

10. Wong, J. and G. Fang. 2006. HURP controls spindle dynamics to promote proper inter-kinetochore tension and efficient kinetochore capture. J. Cell Biol. 173: 879-891.

11. Zhao, W. and G. Fang. 2005. MgcRacGAP controls the assembly of the contractile ring and the initiation of cytokinesis. Proc. Natl. Acad. Sci. USA 102: 13158-13163.

12. Wong, O. and G. Fang. 2005. Plx1 is the 3F3/2 kinase responsible for targeting spindle checkpoint proteins to kinetochores. J. Cell Biol. 170: 709-719.

13. Yu, X., Minter-Dykhouse, K., Malureanu, L., Zhao, W.M., Zhang, D., Merkle, C.J., Ward, I.M., Saya, H., Fang, G., van Deursen. J. and J. Chen. 2005. Chfr is required for tumor suppression and Aurora A regulation. Nature Genetics 37: 401-406.

14. Canman, J.C., Cameron, L., Maddox, P., Tirnauer, J., Straight, A., Mitchison, T., Fang, G., Kapoor, T. and E.D. Salmon. 2003. Stimulation of cytokinesis by asymmetric monopolar spindles. Nature 424: 1074-1078.

15. Kang, D., Chen, J., Wong, J. and G. Fang. 2002. The checkpoint protein Chfr is a ubiquitin ligase that ubiquitinates Plk1 and inhibits Cdc2 at the G2 to M transition. J. Cell Biol. 156: 249-259.

16. Chen, J. and G. Fang. 2001. MAD2B is an inhibitor of the anaphase-promoting complex. Genes & Development 15, 1765-1770.

17. Fang, G., H. Yu and M.W. Kirschner. 1998. Direct binding of the CDC20 protein family activates the anaphase-promoting complex in mitosis and G1. Mol. Cell 2, 163-171.

18. Fang, G., H. Yu and M.W. Kirschner. 1998. The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation. Genes & Development 12, 1871-1883.

19. Fang, G. and T.R. Cech. 1993. The β subunit of Oxytricha telomere-binding protein promotes Gquartet formation by telomeric DNA. Cell 74, 875-885.

20. Fang, G., J.T. Gray, and T.R. Cech. 1993. Oxytricha telomere-binding protein: separable DNA binding and dimerization domains of the α subunit. Genes & Development 7, 870-882.